TONOPAH, Ariz. -- The driver of a tractor-trailer is dead after losing control of his rig and crashing into a caretaker's house at a rest stop near Tonopah, a spokesman for the Arizona Department of Public Safety said.

• Slideshow: Tractor-Trailer Slams Into Home

The victim's name has not yet been released.

The big rig was traveling westbound on Interstate 10 at about 12:15 p.m. when the driver somehow lost control and crossed over the eastbound lanes, said DPS spokesman Bart Graves.

The truck hit a caretaker's residence. Four people were home in the kitchen and backyard at the time of the crash, authorities said.

"Fortunately, one of the subjects could see the trailer coming and told everybody in the backyard to run," said DPS Officer Roger Hansen.

Even so, several of them suffered non-life-threatening injuries and were airlifted to a hospital.

The truck driver was dead at the scene.

Investigators said it doesn't appear as though the driver fell asleep at the wheel, but he may have had a medical episode like a heart attack or stroke. The medical examiner will make the final determination.

Authorities closed the rest stop to allow medical helicopters to fly in and out of the area, Graves said.

The crash did not prompt any I-10 closures. The truck didn't hit any other vehicles as he crossed the lanes, Graves said.

Reporter Greg Gurule contributed to this story.